From: Surrogates are just surrogates, but helpful just the same
Biomarker and menopause status | Tamoxifen | Aromatase inhibitor |
---|---|---|
Breast density premenopause | Marked | NA |
Breast density postmenopause | Minimal | ? |
Serum IGF-1/IGFBP3 ratio | Decrease | No change |
Serum E2 premenopause | Large increase | NA |
Serum E2 postmenopause (no HRT) | Slight increase | Decrease |
Reverse atypia in 6 to 12 months | Doubtful | Doubtful |