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Figure 5 | Breast Cancer Research

Figure 5

From: Intrinsic genetic characteristics determine tumor-modifying capacity of fibroblasts: matrix metalloproteinase-3 5A/5A genotype enhances breast cancer cell invasion

Figure 5

Relationship between matrix metalloproteinase-3 (MMP-3) polymorphism status and MMP release and activation. (a) Relationship between MMP-3 genotype and total MMP-3 release into end-of-assay conditioned media. The tumor fibroblast 5A/5A genotype is associated with higher levels of MMP-3 release compared with the tumor fibroblast 6A/5A genotype (p = 0.07) and the 6A/6A genotype (p = 0.009). Additionally, tumor fibroblasts with the 5A/5A genotype release significantly higher levels of MMP-3 than normal fibroblasts with this genotype. (b) Relationship between MMP-3 genotype, invasion-promoting capacity (IPC), and MMP-3 release. For tumor fibroblasts, there was a correlation between MMP-3 5A/5A genotype, a high IPC phenotype, and high MMP-3 release. (c) Relationship between MMP-3 genotype and (i) pro-MMP-2 and (ii) pro-MMP-9 levels measured by zymography. No significant association between genotype and gelatinolytic activity in normal or tumor fibroblasts was identified. Abs, antibodies. * p =< 0.05

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Breast Cancer Research

ISSN: 1465-542X

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