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Figure 3 | Breast Cancer Research

Figure 3

From: 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice

Figure 3

Effect of CDIM9 on apoptosis and induction of NAG-1 and ATF3. (a) MDA-MB231 cells were treated with Me2SO and 20 μmol/l CDIM9 for 24 hours and apoptotic cells were detected using TUNEL staining. The arrows indicated infrequent apoptotic cells. (b) MDA-MB231 and BT549 cells were treated with Me2SO or 5, 10, and 20 μmol/l CDIM9 for 24 hours. Whole cell lysates were analyzed for NAG-1 and ATF3 by Western blot assays. β-Actin served as loading control. ATF, activating transcription factor; CDIM9, 1,1-bis (3'-indolyl)-1-(p-biphenyl) methane; NAG, nonsteroidal anti-inflammatory drug-activated gene; TUNEL, terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling.

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