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Table 2 Baseline characteristics and baseline bone turnover values in the safety population

From: Effects of steroidal and nonsteroidal aromatase inhibitors on markers of bone turnover in healthy postmenopausal women

 

Mean (SD)

Median (min., max.)

Parameter

Exemestane (n= 22)

Letrozole (n= 20)

Anastrozole (n= 21)

Placebo (n= 21)

Baseline characteristics

Age, years

61 (4.7)

61 (52, 72)

60 (4.7)

60 (47, 69)

57 (5.1)

56 (50, 64)

59 (4.2)

60 (52, 65)

Weight, kg

69 (7.5)

70 (56, 85)

72 (9.4)

70 (59, 95)

66 (7.4)

68 (55, 83)

72 (13)

73 (45, 102)

Height, cm

165 (6.4)

165 (156, 178)

162 (4.7)

163 (149, 170)

163 (5.0)

163 (154, 172)

164 (4.5)

164 (155, 173)

BMI, kg/m2

26 (2.8)

25 (21, 32)

27 (3.5)

28 (22, 35)

25 (2.9)

24 (20, 32)

27 (4.8)

27 (18, 38)

   Time since menopause, years

13 (8.1)

12 (1.0, 28)

12 (7.4)

9.0 (3.0, 25)

12 (6.6)

8.5 (4.0, 25)

10 (5.3)

10 (3.0, 21)

Baseline bone-turnover values*

BAP, ng/ml

16 (7.8)

13 (7.4, 38)

12 (3.3)

11 (6.1, 19)

16 (5.4)

16 (6.8, 25)

14 (3.7)

14 (5.4, 19)

S-CTx, ng/ml

0.51 (0.21)

0.49 (0.23, 0.94)

0.39 (0.12)

0.41 (0.18, 0.59)

0.54 (0.16)

0.58 (0.21, 0.79)

0.41 (0.14)

0.39 (0.16, 0.66)

PINP, ng/ml

57 (25)

55 (21, 106)

44 (12)

41 (25, 74)

53 (20)

51 (13, 92)

48 (19)

45 (23, 96)

U-CTx, μg/mmol Cr

289 (143)

237 (140, 725)

234 (66)

242 (112, 358)

338 (98)

322 (133, 550)

256 (68)

241 (174, 383)

U-NTx, nmol

BCE/mmol Cr

61 (31)

55 (19, 140)

53 (16)

55 (27, 85)

66 (24)

63 (40, 128)

61 (22)

54 (27, 103)

Baseline estrogen concentrations (pg/ml)

E1

34 (15)

31 (11, 72)

30 (11)

28 (13, 51)

31 (12)

28 (14, 61)

30 (11)

27 (10, 61)

E2

4.7 (2.5)

4.4 (1.1, 13)

4.8 (2.1)

4.2 (1.8, 8.6)

6.3 (7.0)

3.9 (1.9, 32)

4.5 (2.1)

3.9 (1.9, 9)

E1S Estrone sulfate

221 (150)

189 (58, 757)

269 (222)

193 (79, 1075)

252 (199)

197 (64, 896)

274 (249)

211 (62, 1156)

Baseline lipid concentrations (mmol/L)

Total cholesterol

5.9 (0.70)

6 (5, 7)

6.1 (0.65)

6 (5, 8)

6.2 (0.82)

6 (4, 8)

5.8 (0.73)

6 (4, 8)

LDL cholesterol

4 (0.8)

4 (2, 6)

4 (0.9)

4 (3, 7)

4 (0.8)

4 (3, 6)

4 (0.7)

4 (2, 6)

HDL cholesterol

1.5 (0.41)

1.4 (0.90, 2.6)

1.5 (0.43)

1.5 (0.87, 2.2)

1.4 (0.39)

1.4 (0.83, 2.4)

1.5 (0.31)

1.4 (1.1, 2.3)

Triglycerides

1.4 (0.81)

1.1 (0.67, 3.7)

1.3 (0.44)

1.2 (0.72, 2.2)

1.3 (0.48)

1.2 (0.54, 2.5)

1.1 (0.42)

1.0 (0.52, 2.1)

  1. *The baseline value was calculated as the mean of three baseline measurements.
  2. BAP, bone alkaline phosphatase; BCE, bone collagen equivalent; BMI, body-mass index; Cr, creatinine; E1, estrone; E1S, estrone sulfate; E2, estradiol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; max; min; PINP, procollagen type I N-terminal peptide; S-CTx, serum C-terminal telopeptide of type I collagen; SD, standard deviation; U-CTx, urine C-terminal telopeptide of type I collagen; U-NTx, urine N-terminal telopeptide of type I collagen.