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Table 2 The effect of chemotherapy agents on tracer uptake after 3-day treatment

From: Application of the multicellular tumour spheroid model to screen PET tracers for analysis of early response of chemotherapy in breast cancer

Treatment Dose (μM) % PET Tracer uptake reduction
   FLT FDG CHO MET ACE
Paclitaxel 1 68 ± 7 21 ± 8 -13 ± 9 6 ± 7 -10 ± 7
  10 69 ± 7 17 ± 7 -6 ± 9 7 ± 7 -10 ± 8
Docetaxel 1 66 ± 6 27 ± 7 -3 ± 7 13 ± 6 1 ± 5
  10 66 ± 6 27 ± 6 -2 ± 7 1 ± 6 -7 ± 5
Doxorubicin 1 76 ± 5 18 ± 5 5 ± 6 -8 ± 5 14 ± 5
  10 95 ± 6 71 ± 6 27 ± 8 38 ± 9 48 ± 7
Tamoxifen 1 11± 8 2 ± 9 -2 ± 9 0 ± 7 -7 ± 7
  10 28 ± 7 22 ± 8 -2 ± 9 -7 ± 7 -45 ± 7
Imatinib 1 7 ± 7 3 ± 9 4 ± 9 -6 ± 7 2 ± 7