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Table 1 Genes downregulated by AI treatment

From: Molecular response to aromatase inhibitor treatment in primary breast cancer

ID

Symbol

Description

Unigene

Fold

LFDR

HSI182A05

TFF1

Trefoil factor 1 (breast cancer, estrogen-inducible)

Hs.162807

0.26

0.09

HSI054D07

HBB

Haemoglobin, beta

Hs.523443

0.31

0.00

HSI047B01

PDZK1

PDZ domain containing 1

Hs.444751

0.35

0.00

HSI035H02

CYP2B6

Cytochrome P450, family 2B6

Hs.1360

0.41

0.04

HSI075H09

AGR2

Anterior gradient 2 homolog (Xenopus laevis)

Hs.530009

0.41

0.08

HSI031E07

STARD10

START domain containing 10

Hs.188606

0.42

0.00

HSI183G10

TFF3

Trefoil factor 3 (intestinal)

Hs.82961

0.43

0.00

HSI147F09

ZBTB20

Zinc finger and BTB domain containing 20

Hs.570657

0.45

0.00

HSI182A08

STC2

Stanniocalcin 2

Hs.233160

0.47

0.00

HSI147F08

KTN1

Kinectin 1 (kinesin receptor)

Hs.509414

0.47

0.00

HSI059H10

LOC143381

Hypothetical protein LOC143381

Hs.388347

0.47

0.00

HSI147F10

MSI2

Musashi homolog 2 (Drosophila)

Hs.134470

0.49

0.00

HSI177G07

EST

Transcribed locus

Hs.443277

0.50

0.10

HSI053H02

UBE2C

Ubiquitin-conjugating enzyme E2C

Hs.93002

0.52

0.10

HSI096C06

MAPT

Microtubule-associated protein tau

Hs.101174

0.52

0.00

HSI049A02

ERGIC1

ER-golgi intermediate compartment 1

Hs.509163

0.53

0.09

HSI040C08

AZGP1

Alpha-2-glycoprotein 1, zinc

Hs.546239

0.55

0.00

HSI133F06

EST

Transcribed locus

Hs.159264

0.55

0.00

HSI182E08

PLAT

Plasminogen activator, tissue

Hs.491582

0.55

0.00

HSI033B05

LY6E

Lymphocyte antigen 6 complex, locus E

Hs.521903

0.56

0.00

HSI048F12

CCND1

Cyclin D1

Hs.523852

0.56

0.10

HSI085G12

KCNK15

Potassium channel, subfamily K, member 15

Hs.528664

0.57

0.00

HSI177H07

PCBP3

Poly(rC) binding protein 3

Hs.474049

0.57

0.10

HSI032D02

ABCA3

ATP-binding cassette, subfamily A3 (ABC1)

Hs.26630

0.57

0.00

HSI182A02

TFF3

Trefoil factor 3 (intestinal)

Hs.82961

0.58

0.04

HSI025A03

FGD3

FYVE, RhoGEF and PH domain containing 3

Hs.411081

0.58

0.00

HSI070B06

AP1S1

Adaptor-related protein complex 1, sigma 1 subunit

Hs.489365

0.58

0.08

HSI057H12

GNB2

Guanine nucleotide binding protein beta 2

Hs.185172

0.58

0.00

HSI080H11

SEMA3F

Semaphorin 3F

Hs.32981

0.59

0.00

HSI054G06

NUSAP1

Nucleolar and spindle associated protein 1

Hs.511093

0.59

0.00

HSI124D07

RIMS4

Regulating synaptic membrane exocytosis 4

Hs.517065

0.59

0.00

HSI065C09

CNNM2

Cyclin M2

Hs.500903

0.59

0.00

HSI080F02

PREX1

PIP3-dependent RAC exchanger 1

Hs.153310

0.59

0.00

HSI095H09

C6orf97

Chromosome 6 open reading frame 97

Hs.130239

0.59

0.00

HSI161G02

EST

Transcribed locus

Hs.570637

0.60

0.00

HSI045G02

UBE2T

Ubiquitin-conjugating enzyme E2T (putative)

Hs.5199

0.60

0.00

HSI046F10

TOP2A

Topoisomerase (DNA) II alpha 170 kDa

Hs.156346

0.60

0.00

HSI183D04

AR

Androgen receptor

Hs.496240

0.61

0.01

HSI183A08

SLC9A3R1

Solute carrier family 9, member 3 regulator 1

Hs.396783

0.61

0.00

HSI025G02

SHARPIN

SHANK-associated RH domain interactor

Hs.529755

0.61

0.08

  1. Shown are the first 40 downregulated genes from a paired SAM analysis, which identified 1,264 genes to be downregulated by aromatase inhibitor (AI) treatment below a local false discovery rate of 1% (LFDR). The genes are ranked according to their fold change.