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Figure 5 | Breast Cancer Research

Figure 5

From: Molecular response to aromatase inhibitor treatment in primary breast cancer

Figure 5

Vector diagrams of metagenes representing estrogen response, proliferation and ECM remodelling. Metagene values derived from the mean values of all the genes in each of the clusters in Figure 4 are plotted and connected with a line from dots (pretreatment values) to arrowheads (post-treatment values). Estrogen metagene values are compared with the (a) proliferation metagene and (b) the extracellular matrix (ECM). The six biopsies with the lowest pretreatment estrogen metagene are coloured in red. The four biopsies with HER2 amplification and high ERBB2 expression are shown with green dots, and samples with the lowest responses in the proliferation metagene are highlighted in blue.

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