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Table 3 Uni- and mutivariate Cox's model (disease-free survival) of prognostic factors

From: Association of TP53codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients

  

Univariate

Multivariate

Variables

n

P value

P value

RR of recurrence (95 percent CI)

TP53 codon 72 status

557

   

   Arg/Arg or Arg/Pro

   

1.0 (referent)

   Pro/Pro

 

0.049

0.047

1.67 (1.01 to 2.76)

MDM2 SNP309 status

557

   

   T/T or T/G

   

1.0 (referent)

   G/G

 

0.41

0.99

1.00 (0.57 to 1.75)

Tumor size

545

   

   <2 cm

   

1.0 (referent)

   ≥2 cm

 

0.001

0.69

1.14 (0.61 to 2.12)

Lymph node

519

   

   Negative

   

1.0 (referent)

   Positive

 

<0.0001

<0.0001

4.09 (2.35 to 7.12)

ER status

525

   

   Positive

   

1.0 (referent)

   Negative

 

<0.0001

0.002

2.48 (1.40 to 4.39)

Grade

272

   

   1

   

1.0 (referent)

   2 or 3

 

0.009

0.29

1.50 (0.71 to 3.14)

p53 IHC status

268

   

   Negative

   

1.0 (referent)

   Positive

 

0.18

0.14

0.64 (0.35 to 1.16)

  1. CI, confidence interval; ER, estrogen receptor; IHC, immunohistochemistry; RR, risk ratio.
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Breast Cancer Research

ISSN: 1465-542X

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