Table 5 Correlation between FGFR1 gene amplification and the clinicopathological variables in the oestrogen-receptor-positive group
From: FGFR1 amplification in breast carcinomas: a chromogenic in situhybridisation analysis
Parameter | Number of samples | Positive FGFR1 amplification number (%) | P value |
|---|---|---|---|
Age | 313 | Â | Not significant |
   <50 years | 95 | 6 (6.3) |  |
   ≥50 years | 218 | 21 (9.6) |  |
Grade | 313 | Â | Not significant |
   1 | 99 | 8 (8.1) |  |
   2 | 120 | 10 (8.3) |  |
   3 | 94 | 9 (9.6) |  |
Size | 313 | Â | Not significant |
   ≥1.5 cm | 188 | 19 (10.1) |  |
   <1.5 cm | 125 | 8 (6.4) |  |
Lymph node stage | 311 | Â | Not significant |
   N0 | 214 | 19 (8.9) |  |
   N1 | 74 | 6 (8.2) |  |
   N2 | 23 | 2 (9.3) |  |
Nottingham Prognostic Index | 311 | Â | Not significant |
   Good | 148 | 11 (7.4) |  |
   Moderate | 133 | 14 (10.5) |  |
   Poor | 30 | 2 (6.7) |  |
Distant metastasis | 313 | Â | 0.032 |
   No | 273 | 20 (7.3) |  |
   Definite | 40 | 7 (17.5) |  |
Vascular invasion | 303 | Â | Not significant |
   No | 224 | 18 (8) |  |
   Yes | 79 | 8 (10.1) |  |
Progesterone receptor | 305 | Â | 0.05 |
   Negative | 80 | 11 (13.8) |  |
   Positive | 225 | 15 (6.7) |  |
HER2 | 299 | Â | 0.063 |
   Negative | 179 | 20 (11.2) |  |
   Positive | 120 | 6 (5.0) |  |
Androgen receptor | 283 | Â | 0.08 |
   Negative | 90 | 11 (12.2) |  |
   Positive | 193 | 12 (6.2) |  |
Cytokeratin 7/8 | 310 | Â | Not significant |
   Negative | 73 | 8 (11) |  |
   Positive | 237 | 19 (8.0) |  |
Cytokeratin 18 | 269 | Â | Not significant |
   Negative | 46 | 1 (2.2) |  |
   Positive | 223 | 21 (9.4) |  |
Cytokeratin 19 | 308 | Â | Not significant |
   Negative | 33 | 4 (12.1) |  |
   Positive | 275 | 22 (8.0) |  |
Cytokeratin 5/6 | 306 | Â | Not significant |
   Negative | 261 | 24 (9.2) |  |
   Positive | 45 | 2 (4.4) |  |
Cytokeratin 14 | 299 | Â | Not significant |
   Negative | 252 | 23 (9.1) |  |
   Positive | 47 | 2 (4.3) |  |
Epidermal growth factor receptor | 242 | Â | Not significant |
   Negative | 209 | 19 (9.1) |  |
   Positive | 33 | 2 (6.1) |  |
Basal markers [27] | 297 | Â | Not significant |
   Negative | 234 | 22 (9.4) |  |
   Positive | 63 | 3 (4.8) |  |