Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

Table 5 Mean percentage mammographic density (MD) according to IGFBP-1 and IGFBP-3 haplotype-tagging SNPs

SNP	Genotype	n	Mean percentage MD^a	p for trend^b
15	G/G	120	26.4	0.39
	A/G	452	27.3
	A/A	548	26.2
16	A/A	36	24.0	0.41
	A/G	377	28.0
	G/G	707	26.3
17	G/G	56	25.3	0.75
	C/G	405	26.9
	C/C	635	26.5
18	A/A	1	11.9	0.18
	A/G	59	23.8
	G/G	1,060	26.9
19	A/A	158	28.4	0.006
	G/A	543	27.3
	G/G	409	24.8
20	T/T	5	21.7	0.06
	C/T	97	23.6
	C/C	1,017	27.0
21	G/G	120	28.2	0.81
	A/G	502	25.6
	A/A	465	27.3
22	T/T	108	28.1	0.44
	C/T	441	27.1
	C/C	557	26.3
23	T/T	35	28.2	0.67
	C/T	336	26.9
	C/C	715	26.5
24	A/A	195	24.8	0.55
	A/G	517	27.4
	G/G	378	26.5
25	C/C	148	25.5	0.86
	G/C	511	27.0
	G/G	383	26.3
26	T/T	202	26.4	0.87
	T/G	605	26.2
	G/G	282	26.5
27	T/T	49	23.4	0.80
	T/G	362	27.4
	G/G	673	26.4
28	A/A	47	27.6	0.65
	T/A	359	26.2
	T/T	700	26.9
29	C/C	44	24.0	0.16
	T/C	346	26.2
	T/T	706	27.1

IGFBP, insulin-like growth factor binding protein. ^aMultivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user); ^b p for trend based on inclusion of genotype as an ordinal variable in models with square-root-transformed mammographic density as the dependent variable. The result in bold is significant (p ≤ 0.05).

ISSN: 1465-542X