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Table 3 Common IGFBP-1 and IGFBP-3 haplotypesa and percentage mammographic density, Nurses' Health Study

From: Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study

Block 1 (p = 0.17)b

Block 2 (p = 0.11)b

Block 3 (p = 0.53)b

Haplotype

Frequency (percentage)

βc (95% CI)

Haplotype

Frequency (percentage)

βc (95% CI)

Haplotype

Frequency (percentage)

βc (95% CI)

1A (AGCGG)

24.7

-0.12

2A (CACC)

35.5

-0.10

3A (GCTG)

37.0

-0.004

  

(-0.29 to 0.04)

  

(-0.25 to 0.06)

  

(-0.16 to 0.15)

1B (AGGGG)

22.6

-0.06

2B (CCTC)

27.8

-0.07

3B (AGGT)

20.6

-0.005

  

(-0.23 to 0.12)

  

(-0.23 to 0.08)

  

(-0.19 to 0.17)

1C (AACGA)

19.5

0.07

2C (CGCC)

17.3

0.17

3C (AGGG)

19.4

0.003

  

(-0.11 to 0.25)

  

(-0.03 to 0.37)

  

(-0.19 to 0.19)

1D (GGCGA)

18.7

0.20

2D (CGCT)

13.4

0.15

3D (GGGG)

13.0

0.02

  

(0.01 to 0.38) d

  

(-0.06 to 0.37)

  

(-0.20 to 0.24)

1E (GGCGG)

10.0

-0.05

Rare

6.0

-0.18

3E (GGTG)

6.7

0.18

  

(-0.29 to 0.19)

  

(-0.57 to 0.20)

  

(-0.12 to 0.48)

Rare

4.5

-

   

Rare

3.4

 
  1. CI, confidence interval; IGFBP, insulin-like growth factor binding protein. aIGFBP1/IGFBP3 haplotype blocks are based on SNPs defined in Table 1. Block 1, SNPs 15 to 19; block 2, SNPs 20 to 23; block 3, SNPs 24 to 27. bGlobal test of association based on F statistic comparing model with haplotypes in block and covariates with covariates only. cβ coefficients from models that used square-root-transformed mammographic density as the dependent variable. Multivariate-adjusted models including age (continuous), body mass index (continuous), alcohol consumption (category), age at first birth/parity, history of benign breast disease (yes/no), family history of breast cancer (yes/no), menopausal status/postmenopausal hormone use (premenopausal, postmenopausal never user, postmenopausal current user, postmenopausal past user). Results in bold show significant differences: d p = 0.04.