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Figure 6 | Breast Cancer Research

Figure 6

From: Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells

Figure 6

T-oligo effect on MCF-7 cells is comparable to that of cisplatin and ICI 182,780. MCF-7 cells were treated with cisplatin (10 μM), the anti-estrogen ICI 182,780 (100 nM) or T-oligo (40 μM) once and cell yields were determined at different intervals. (a) Within 5 days cisplatin decreased MCF-7 yield by 82 ± 0.1% and T-oligo did so by 79 ± 0.02% compared to diluent. The difference between the T-oligo and cisplatin effects was not significant (p = 1.0). (b) Compared to diluent, ICI 182,780 or T-oligo caused decreases in cell yield of MCF-7 cells of 72 ± 0.1% and 84 ± 0.02%, respectively. T-oligo was significantly more effective than ICI 182,780 (p < 0.005).

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