Skip to main content
Figure 1 | Breast Cancer Research

Figure 1

From: Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas

Figure 1

Hierarchical clustering analysis of 194 breast tumor samples analyzed using the 'SAM264' patient survival associated gene set augmented with nine additional genes included in the resequencing analysis. (a) Hierarchical clustering overview that shows the overall context for the 21 genes. (b) Close up of the sample associated dendrogram, which identifies the tumor samples that were re-sequenced in red. (c) Luminal/ER+ epithelial gene set showing coordinated expression of ESR1, GATA3, FOXA1, and XBP1. (d) Proliferation gene set showing expression of STK6, MYBL2, and PLK1. (e) Basal epithelial gene set showing the expression of FOXC1 and FZD7. (f) The expression profiles of the additional genes that were re-sequenced but that did not fall into the previous expression patterns are shown, and their position in the larger cluster is also shown in panel a. All genes identified in red text were analyzed by re-sequencing in this study, and only FBXW7 and PIN1 were not included in this cluster analysis because their average expression levels did not meet the gene filtering criteria. ER, estrogen receptor.

Back to article page