From: IGFBP3mRNA expression in benign and malignant breast tumors
Status | Disease | Tumor tissue | Adjacent tissue | ||
---|---|---|---|---|---|
 |  | No. of patients | IGFBP3 mRNA level | No. of patients | IGFBP3 mRNA level |
Premenopausal | BBD | 88 | 231.6 (147.8, 488.0) | 54 | 178.9 (104.6, 300.3) |
 | Breast cancer | 91 | 146.2 (85.2, 289.2) | 41 | 199.4 (156.6, 274.1) |
 | p a |  | <0.001 |  | 0.472 |
 | BBD |  |  |  |  |
 |    Non-proliferative lesions | 53 | 185.4 (109.6, 279.4) | 31 | 139.2 (100.2, 243.2) |
 |    Proliferative lesions | 35 | 353.1 (197.9, 709.3) | 23 | 219.1 (141.8, 394.3) |
 | p a |  | 0.006 |  | 0.055 |
 | Breast cancer (by stage) |  |  |  |  |
 |    0 and I | 23 | 125.0 (102.7, 169.0) | 16 | 203.1 (85.4, 263.9) |
 |    IIa | 36 | 196.5 (86.7, 337.6) | 16 | 200.9 (126.8, 344.1) |
 |    IIb, III & IV | 32 | 139.1 (78.9, 301.8) | 9 | 199.4 (165.1, 235.0) |
 | p for trend testa |  | 0.775 |  | 0.740 |
Postmenopausal | BBD | 7 | 314.2 (183.9, 528.5) | 5 | 201.8 (73.9, 390.0) |
 | Breast cancer | 50 | 121.8 (96.3, 223.2) | 21 | 208.2 (167.1, 362.8) |
 | p a |  | 0.006 |  | 0.184 |
 | BBD |  |  |  |  |
 |    Non-proliferative lesions | 4 | 249.1 (119.4, 421.3) | 3 | 201.8 (29.5, 390.0) |
 |    Proliferative lesions | 3 | 472.6 (274.5, 1500.8) | 2 | 239.5 (73.9, 405.1) |
 | p a |  | 0.157 |  | 0.763 |
 | Breast cancer (by stage) |  |  |  |  |
 |    0 and I | 9 | 126.7 (116.8, 220.8) | 5 | 221.0 (155.2, 262.6) |
 |    IIa | 26 | 112.1 (96.3, 202.2) | 10 | 206.9 (179.0, 382.1) |
 |    IIb, III & IV | 15 | 141.1 (72.7, 351.8) | 6 | 243.9 (159.0, 727.6) |
 | p for trend testa |  | 0.670 |  | 0.308 |