A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)

Table 2 Association between breast cancer and individual htSNPs in the AR across the BPC3 cohorts

SNP	Genotype	Cases (percentage)^a	Controls (percentage)^a	OR (95% CI)^b	P trend^c	P heterogeneity^d
AR_001	AA	4,480 (82)	6,034 (83)	1.00 (Ref.)	.	.
rs962458	AG	826 (15)	1,054 (14)	1.04 (0.95 to 1.15)	.	.
	GG	146 (3)	187 (3)	1.02 (0.83 to 1.26)	0.50	0.96
AR_002	GG	3,833 (71)	5,073 (70)	1.00 (Ref.)	.	.
rs6152	GA	1,324 (25)	1,815 (25)	0.98 (0.90 to 1.06)	.	.
	AA	245 (5)	314 (4)	1.02 (0.87 to 1.20)	0.89	0.84
AR_003	GG	3,773 (70)	4,984 (69)	1.00 (Ref.)	.	.
rs1204038	GA	1,279 (24)	1,762 (24)	0.97 (0.90 to 1.06)	.	.
	AA	365 (7)	452 (6)	1.05 (0.89 to 1.23)	0.96	0.86
AR_004	AA	4,940 (90)	6,540 (90)	1.00 (Ref.)	.	.
rs2361634	AG	524 (9)	727 (10)	0.95 (0.85 to 1.07)	.	.
	GG	25 (<1)	24 (<1)	1.30 (0.76 to 2.21)	0.70	0.56
AR_005	AA	4,601 (84)	6,188 (85)	1.00 (Ref.)	.	.
rs1337080	AG	802 (15)	1,012 (14)	1.07 (0.97 to 1.18)	.	.
	GG	65 (1)	81 (1)	1.06 (0.80 to 1.41)	0.20	0.88
AR_006	AA	3,442 (63)	4,596 (63)	1.00 (Ref.)	.	.
rs1337082	AG	1,601 (29)	2,154 (29)	1.01 (0.94 to 1.09)	.	.
	GG	416 (8)	556 (8)	0.99 (0.85 to 1.14)	0.97	0.29

^aNumbers of cases and controls genotyped for each SNP vary due to assay failure; ^bunadjusted logistic regression, conditional on matching factors and cohort as described in text; ^ctest for trend for log-additive or codominant model; ^dtest for heterogeneity in ORs across cohorts. AR, androgen receptor; BPC3, Breast and Prostate Cancer Cohort Consortium; CI, confidence interval; htSNP, haplotype-tagging single nucleotide polymorphism; OR, odds ratio; Ref., Reference category; SNP, single nucleotide polymorphism.

ISSN: 1465-542X