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HER-2 activation and TP53 inactivation as predictors of survival in breast cancer

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Activation of the HER-2 proto-oncogene and inactivation of the TP53 tumour-suppressor gene belong to the most common genetic changes in human breast carcinomas. Both appear to be of prognostic significance, at least in patients with node-positive disease. The relevance of these changes in node-negative disease, however, still remains uncertain. Moreover, the relationship between HER-2 and TP53 status remains to be fully clarified.

HER-2 and TP53 status were determined in 261 breast carcinomas collected from Norwegian breast cancer patients diagnosed between 1984 and 1994. HER-2 status was determined using immunohistochemistry. A subset of the tumours was also examined with regard to gene amplification using the Southern blot technique. A significant association was found between the presence of gene amplification and positive HER-2 immunostaining in the tumour. The tumours were also examined for TP53 alterations using CDGE (constant denaturant gel electrophoresis) and immunohistochemistry. A significant association was found between the presence of HER-2 activation and TP53 inactivation in the tumour. Survival analyses will be presented.

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Andersen, T., Skovlund, E., Bukholm, I. et al. HER-2 activation and TP53 inactivation as predictors of survival in breast cancer. Breast Cancer Res 2, P3.07 (2000) doi:10.1186/bcr158

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Keywords

  • Breast Cancer
  • Breast Carcinoma
  • Gene Amplification
  • Human Breast Carcinoma
  • TP53 Status