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Figure 3 | Breast Cancer Research

Figure 3

From: Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer

Figure 3

Examples of receptor expression and growth. This figure shows photomicrographs of representative examples of normal TDLUs and HELUs immunostained for ER-α, the proliferation-associated marker Ki67, and apoptosis (as assessed using the TUNEL assay). In general, HELUs exhibited much higher levels of ER-α expression than did TDLUs. Expression of progesterone receptor was similar to that of ER-α (not shown). Proliferation was also significantly higher on average in HELUs than in TDLUs. In contrast, apoptotic rates were somewhat lower in HELUs than in TDLUs. The dark (black) nuclei are positive for ER-α, Ki67 (some circled), and apoptosis (some circled) in each panel. ER, estrogen receptor; HELU, hyperplastic enlarged lobular unit; TDLU, terminal duct lobular unit; TUNEL, terminal transferase-mediated dUTP nick end-labeling.

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