Number of cancers, age under 70 years | Model | BRCA1 | BRCA2 | Noncarriers | |||
---|---|---|---|---|---|---|---|
 |  | Observed | Expected | Observed | Expected | Observed | Expected |
≥3 BC, ≥1 OC | BOADICEA | ||||||
 |    Full pedigrees | 9 | 6.92 | 4 | 3.80 | 21 | 23.28 |
 |    Second-degree relatives | 6 | 3.12 | 1 | 1.49 | 7 | 9.38 |
 | BRCAPRO | 6 | 7.80 | 1 | 2.35 | 7 | 3.98 |
≥4 BC, 0 OC | BOADICEA | ||||||
 |    Full pedigrees | 2 | 6.20 | 14 | 14.75 | 90 | 85.05 |
 |    Second-degree relatives | 2 | 4.11 | 12 | 8.60 | 57 | 58.29 |
 | BRCAPRO | 2 | 19.40 | 12 | 8.27 | 57 | 43.37 |
3 BC, 0 OC | BOADICEA | ||||||
 |    Full pedigrees | 0 | 0.82 | 1 | 1.20 | 25 | 23.97 |
 |    Second-degree relatives | 1 | 1.09 | 2 | 1.77 | 37 | 37.13 |
 | BRCAPRO | 1 | 5.43 | 2 | 2.97 | 37 | 31.60 |
2 BC, any OC | BOADICEA | ||||||
 |    Full pedigrees | 3 | 1.75 | 0 | 0.34 | 19 | 19.91 |
 |    Second-degree relatives | 5 | 3.83 | 4 | 1.40 | 54 | 57.79 |
 | BRCAPRO | 5 | 9.53 | 4 | 2.08 | 54 | 51.50 |