Skip to main content

Table 3 Observed and expected number of mutations among the first screened individuals by number of cancers in the family

From: BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families

Number of cancers, age under 70 years

Model

BRCA1

BRCA2

Noncarriers

  

Observed

Expected

Observed

Expected

Observed

Expected

≥3 BC, ≥1 OC

BOADICEA

 

   Full pedigrees

9

6.92

4

3.80

21

23.28

 

   Second-degree relatives

6

3.12

1

1.49

7

9.38

 

BRCAPRO

6

7.80

1

2.35

7

3.98

≥4 BC, 0 OC

BOADICEA

 

   Full pedigrees

2

6.20

14

14.75

90

85.05

 

   Second-degree relatives

2

4.11

12

8.60

57

58.29

 

BRCAPRO

2

19.40

12

8.27

57

43.37

3 BC, 0 OC

BOADICEA

 

   Full pedigrees

0

0.82

1

1.20

25

23.97

 

   Second-degree relatives

1

1.09

2

1.77

37

37.13

 

BRCAPRO

1

5.43

2

2.97

37

31.60

2 BC, any OC

BOADICEA

 

   Full pedigrees

3

1.75

0

0.34

19

19.91

 

   Second-degree relatives

5

3.83

4

1.40

54

57.79

 

BRCAPRO

5

9.53

4

2.08

54

51.50

  1. BC, breast cancer; OC, ovarian cancer.