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Table 4 Prognostically significant variables in phyllodes tumors as determined by univariate analysis of disease-free survival (DFS)

From: Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast

Variable

Number of patients

Number of patients with disease (%)

Number of disease-free patients (%)

Mean DFS (months [95% confidence interval])

P value

Log-rank

p53 stroma

      

   <10%

24

5 (21)

19 (79)

173 (142–204)

<0.001

10.97

   ≥10%

6

5 (83)

1 (16)

61 (23–98)

  

HIF-1α stroma

      

   <1%

15

3 (20)

12 (80)

180 (146–214)

0.032

4.59

   ≥1%

15

7 (47)

8 (53)

103 (64–142)

  

Ki67 stroma

      

   <10%

16

4 (25)

12 (75)

176 (145–207)

0.028

4.85

   ≥10%

14

6 (43)

8 (57)

91 (55–127)

  

Grade

      

   Benign

15

4 (27)

11 (73)

165 (130–200)

0.039

6.48

   Borderline

5

1 (20)

4 (80)

140 (86–194)

  

   Malignant

10

5 (50)

5 (50)

71 (32–109)

  
  1. HIF-1α, hypoxia-inducible factor 1 alpha.