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Table 1 Differences in the expression of hypoxia related proteins, microvasculature and proliferation in fibroepithelial breast tumors

From: Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast

Marker

Fibroadenoma (n = 30)

Phyllodes tumor (n = 37)

P valuea

Stroma

   

   HIF-1α

2 (7%)

19 (51%)

0.001

   CAIX

0 (0%)

2/36 (6%)

0.497

   VEGF

7 (23%)

17 (47%)

0.074

   Ki67

1 (3%)

17 (47%)

<0.001

   Hot-spot microvessel count

13 (43%)

22/35 (63%)

0.140

   Global microvessel count

13 (43%)

20/35 (57%)

0.324

   p53

0(0%)

7/36(19%)

0.014

Epithelium

   

   HIF-1α

0 (0%)

15/35 (43%)

<0.001

   CAIX

0 (0%)

9/35 (26%)

0.003

   VEGF

22 (73%)

22/36 (61%)

0.432

   Ki67

2 (7%)

2/36 (6%)

1.000

   p53

0(0%)

0(0%)

-

  1. Due to empty blocks, repeated unsuccessful staining attempts or too little epithelium in a malignant tumor, numbers varied slightly for some stainings. Dichotomized values were used. aUsing the chi-square test, P values below 0.05 were regarded as significant. HIF-1α = hypoxia-inducible factor 1 alpha, CAIX = carbonic anhydrase IX, VEGF = vascular endothelial growth factor.