Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer

Table 5 Comparison of immunohistochemistry scores for hormone receptors in primary and secondary tumors

Receptor	Primary tumors^a	Secondary tumors^a	P
ER-α (1D5)	4.9 ± 2.7	3.1 ± 3.2	0.049*
ER-α Ser118	4.9 ± 2.8	7.3 ± 1.6	0.0098*
ER-α Ser167	3.7 ± 1.6	5.5 ± 2.2	0.11
ER-β1	5.5 ± 2.2	7.0 ± 2.0	0.041*
ER-βcx/β2	4.1 ± 2.6	6.1 ± 2.6	0.049*
PR (636)	4.1 ± 3.2	2.9 ± 3.5	0.057
PRA	3.5 ± 2.6	6.1 ± 2.6	0.018*
PRB	3.7 ± 2.4	5.7 ± 2.6	0.027*

^aMean ± SD. n = 10. *P <0.05. ER, estrogen receptor; PR(A,B), progresterone receptor (A,B).

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