aFISH: I, increased LRIG1 copy number; NL, normal LRIG1 copy number. bWestern blot: comparison of the staining in tumour tissue (T) and non-neoplastic tissue (NN). A visual increase (In)/decrease (D) of at least 50% was considered convincing. E, equal levels of protein. cLRIG1 RT-PCR T/NN; LRIG1 mRNA expression level in neoplastic (T) tissue samples divided by levels in matched non-neoplastic (NN) tissue samples. dAs described in the results, at p.9, ratios >1.2 are regarded as significant overexpression and ratios <0. 8 are regarded as significant underexpression in neoplastic tissue compared to non-neoplastic tissue. Samples were consecutively collected. eTwo tumours did not yield RNA of sufficient quality for the RT-PCR analysis.