The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

Breast Cancer Research

Table 1 Relations between protein^a expression and clinicopathological characteristics in patients with breast cancer

Characteristic	Cks1			Skp2			p27^Kip1
	High	Low	P ^b	High	Low	P ^b	High	Low	P ^b
Grade
1	2	8	0.012	2	8	0.005	2	8	0.032
2	14	14	0.012	7	21	0.005	14	14	0.032
3	10	2	0.012	9	3	0.005	8	4	0.032
Tumor size^c
T1	15	18	0.333	10	23	0.265	19	14	0.485
T2	10	6	0.333	7	9	0.265	8	8	0.485
T3	1	0	0.333	1	0	0.265	0	1	0.485
Lymph node involvement^c
N0	16	15	0.508	11	20	0.803	18	13	0.387
N1	6	3	0.508	4	5	0.803	3	6	0.387
N2	4	6	0.508	3	7	0.803	6	4	0.387
Estrogen receptor expression
Negative	17	6	0.013	16	7	0.001	9	14	0.048
Positive	10	17	0.013	3	24	0.001	17	10	0.048
Progesterone receptor expression
Negative	15	3	0.006	14	4	0.001	5	13	0.032
Positive	12	20	0.006	4	27	0.001	20	12	0.032
Age (years)
>50	14	5	0.017	12	7	0.002	7	12	0.051
< 50	12	19	0.017	25	6	0.002	20	11	0.051

^aCks1, cyclin kinase subunit 1; p27^Kip1, a cell-cycle inhibitory protein; Skp2, S-phase kinase protein 2. ^bRefers to the differences between protein expression and the variables. ^cAccording to the TNM (tumor, node, metastases) staging system of the American Joint Committee on Cancer. P ≤ 0.05 (values shown in bold type) was considered statistically significant.

ISSN: 1465-542X