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Table 1 Relations between proteina expression and clinicopathological characteristics in patients with breast cancer

From: The expression of the ubiquitin ligase subunit Cks1 in human breast cancer

Characteristic Cks1 Skp2 p27Kip1
  High Low P b High Low P b High Low P b
Grade          
   1 2 8 0.012 2 8 0.005 2 8 0.032
   2 14 14 0.012 7 21 0.005 14 14 0.032
   3 10 2 0.012 9 3 0.005 8 4 0.032
Tumor sizec          
   T1 15 18 0.333 10 23 0.265 19 14 0.485
   T2 10 6 0.333 7 9 0.265 8 8 0.485
   T3 1 0 0.333 1 0 0.265 0 1 0.485
Lymph node involvementc          
   N0 16 15 0.508 11 20 0.803 18 13 0.387
   N1 6 3 0.508 4 5 0.803 3 6 0.387
   N2 4 6 0.508 3 7 0.803 6 4 0.387
Estrogen receptor expression          
   Negative 17 6 0.013 16 7 0.001 9 14 0.048
   Positive 10 17 0.013 3 24 0.001 17 10 0.048
Progesterone receptor expression          
   Negative 15 3 0.006 14 4 0.001 5 13 0.032
   Positive 12 20 0.006 4 27 0.001 20 12 0.032
Age (years)          
   >50 14 5 0.017 12 7 0.002 7 12 0.051
   < 50 12 19 0.017 25 6 0.002 20 11 0.051
  1. aCks1, cyclin kinase subunit 1; p27Kip1, a cell-cycle inhibitory protein; Skp2, S-phase kinase protein 2. bRefers to the differences between protein expression and the variables. cAccording to the TNM (tumor, node, metastases) staging system of the American Joint Committee on Cancer. P ≤ 0.05 (values shown in bold type) was considered statistically significant.