Table 1 Somatic mutation of PIK3CA in breast cancer cell lines and primary tumors
From: Somatic mutation and gain of copy number of PIK3CA in human breast cancer
Exon | Nucleotide | Amino acid | Functional domain | Cell lines | Tumors | Total |
|---|---|---|---|---|---|---|
9 | C1616G | P539R | Helical | 1 (BT20) | 1 | Â |
9 | G1624A | E542K | Helical | Â | 3 | 3 |
9 | G1633A | E545K | Helical | 2 (MDA361, MCF7) | 8 | 10 |
9 | A1634G | E545G | Helical | Â | 1 | 1 |
20 | A3140G | H1047R | Kinase | 2 (BT20, UACC893) | 5 | 5 |
20 | A3140T | H1047L | Kinase | Â | 1 | Â |
No. with mutations | Â | 5 | 19 | 22 | ||
No. samples screened | Â | 15 | 92 | Â | ||
Percent of cases with mutations | Â | 33.3 | 20.6 | Â | ||