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Figure 1 | Breast Cancer Research

Figure 1

From: Sex-hormone binding globulin receptor-mediated growth inhibition in breast cancer cells: a proteomics approach

Figure 1

Model for SHBG-mediated signaling. The plasma membrane binding site for SHBG is preferentially expressed in ER+ cells with a reduced proliferative index [2-4]. SHBG-R only binds steroid-free or unliganded SHBG. Following binding of unliganded SHBG to SHBG-R on the cell membrane, E2 binds to the SHBG–SHBG-R complex, thereby activating it. Activation induces the synthesis of cAMP, which, in turn, triggers downstream signaling via PKA [2-4]. The biological outcome of this signaling pathway in cells of the human breast carcinoma cell line MCF-7 is decreased E2-mediated cell growth.

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