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Table 1 CYP17 genotypes and breast cancer risk by menopausal status (BRCA1 and BRCA2 mutation carriers excluded)

From: CYP17genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study

Genotype

Cases, n (%)

Controls, n (%)

Crude OR (95% CI)

Adjusted OR (95% CI)a

Premenopausal

    

A 1/A 1 (TT)

414 (40)

201 (38)

1.00

1.00

A 1/A 2 (TC)

460 (44)

253 (48)

0.88 (0.70, 1.11)

0.90 (0.71, 1.14)

A 2/A 2 (CC)

169 (16)

75 (14)

1.09 (0.79, 1.51)

1.08 (0.78, 1.51)

Postmenopausal

    

A 1/A 1 (TT)

99 (41)

66 (44)

1.00

1.00

A 1/A 2 (TC)

105 (44)

64 (43)

1.09 (0.70, 1.70)

1.32 (0.82, 2.12)

A 2/A 2 (CC)

37 (15)

20 (13)

1.23 (0.66, 2.31)

1.29 (0.66, 2.52)

Pooled

    

A 1/A 1 (TT)

513 (40)

267 (39)

1.00

1.00

A 1/A 2 (TC)

565 (44)

317 (47)

0.93 (0.76, 1.14)

0.96 (0.77, 1.18)

A 2/A 2 (CC)

206 (16)

95 (14)

1.13 (0.85, 1.50)

1.12 (0.83, 1.51)

No family historyb

    

A 1/A 1 (TT)

462 (40)

249 (39)

1.00

1.00

A 1/A 2 (TC)

501 (44)

296 (47)

0.91 (0.74, 1.13)

0.95 (0.76, 1.18)

A 2/A 2 (CC)

182 (16)

91 (14)

1.08 (0.80, 1.45)

1.10 (0.81, 1.49)

With family historyb

    

A 1/A 1 (TT)

51 (37)

18 (42)

1.00

1.00

A 1/A 2 (TC)

64 (46)

21 (49)

1.08 (0.52, 2.23)

1.08 (0.49, 2.36)

A 2/A 2 (CC)

24 (17)

4 (9)

2.12 (0.65, 6.94)

2.46 (0.70, 8.60)

  1. aOdds ratio (OR) adjusted for reference age, body mass index, family history defined by any first-degree relative who had breast cancer, state, education level, country of birth, benign breast lump and age at menopause in postmenopausal women.
  2. bFamily history defined by any first-degree relative who had breast cancer.