Genetic polymorphisms in the matrix metalloproteinase 12 gene (MMP12) and breast cancer risk and survival: the Shanghai Breast Cancer Study

Table 2 Association of MMP12 A-82G and A1082G polymorphisms with breast cancer risk

MMP12 genotype	Cases	Controls	Crude OR (95% CI)	Adjusted OR^a (95% CI)
	No. (%)	No. (%)
A-82G
AA	1063 (95.1)	1153 (94.3)	1.0	1.0
AG	51 (4.6)	69 (5.6)	0.9 (0.6–1.2)	0.9 (0.6–1.3)
GG	4 (0.3)	1 (0.1)
A1082G (Asn357Ser)
AA	739 (80.2)	784 (80.3)	1.0	1.0
AG	159 (17.2)	175 (17.9)	1.0 (0.8–1.3)	1.0 (0.8–1.3)
GG	24 (2.6)	17 (1.8)
Presence of any minor genotypes^b
No	687 (75.4)	731 (75.4)	1.0	1.0
Yes	224 (24.6)	239 (24.6)	1.0 (0.8–1.2)	1.0 (0.8–1.2)

^aAdjusted for age, education, age at menarche, menopausal status, age at menopause, age at first live birth, waist-to-hip ratio, and physical activity during past 10 years. ^bAG/GG genotypes for A-82G and AG/GG genotype for A1082G polymorphisms. CI, confidence interval; OR, odds ratio.

ISSN: 1465-542X