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Figure 3 | Breast Cancer Research

Figure 3

From: Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells

Figure 3

Treatment with AG1024 enhances apoptotic effects of gefitinib. (a) Flow cytometric analysis of apoptosis in cells stained with annexin V and propidium iodide after 72-hour treatment of breast cancer cells with AG1024 (AG), gefitinib (GE), or both. (b) Flow cytometric analysis of caspase-3 induction by Red-DEVD-FMK fluorescence after 24-hour treatment of cells with AG1024, gefitinib, or both. Addition of AG1024 to gefitinib treatment significantly enhanced apoptotic induction over levels achieved by gefitinib alone. Values on horizontal axes are concentrations (μM). *P < 0.05.

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