Treatment | MDA-MB-231 |
P value | MDA-MB-468 |
P value |
---|
Vehicle | 430.0 ± 178.2 |  | 76.6 ± 15.2 |  |
Celecoxib 20 μmol/l | 30.1 ± 2.9 | <0.01 | 39.0 ± 16.5 | 0.03 |
Celecoxib 40 μmol/l | 30.7 ± 4.7 | <0.01 | 37.3 ± 11.0 | 0.02 |
Celecoxib 60 μmol/l | 37.7 ± 13.6 | <0.01 | 30.3 ± 13.6 | 0.01 |
- Forty-eight hours post treatment, conditioned medium from vehicle and celecoxib (20–60 μmol/l) treated cells were harvested and prostaglandin (PG)E2 levels (pg/ml) determined by enzyme-linked immunosorbent assay. In all cell lines, PGE2 levels were significantly reduced at all doses of celecoxib. The experiment was repeated three times and in triplicate. P values represent significant differences between vehicle control and celecoxib treatment.