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Table 2 Distribution of breast cancer risk factors according to arylamine N-acetyltransferase activity (acetylation status)

From: A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology

 

NAT2

  
 

Fast

Slow

  

Characteristic

No. (%)

No. (%)

OR

95% CI

Age (years)

    

   <50a

22 (12)

38 (12)

1.0

-

   50 to 59

15 (8)

28 (9)

1.1

0.5 to 2.4

   60 to 69

59 (32)

103 (32)

1.0

0.5 to 1.9

   70+

86 (47)

151 (47)

1.0

0.6 to 1.8

Alcohol use

    

   Nondrinkera

45 (14)

32 (18)

1.0

-

   ≤ 1 drink/month

75 (23)

43 (24)

1.2

0.7 to 2.2

   Few drinks/month

77 (24)

39 (21)

1.4

0.8 to 2.5

   Few drinks/week

76 (24)

39 (21)

1.4

0.8 to 2.5

   Almost every day

40 (12)

24 (13)

1.2

0.6 to 2.3

   Unknown

7 (2)

5 (3)

1.0

0.3 to 3.4

Body mass index (BMI) (kg/m2)

    

   <20.0a

30 (17)

59 (19)

1.0

-

   20.0 to 24.9

114 (65)

196 (62)

0.9

0.5 to 1.4

   25.0 to 29.9

24 (14)

50 (16)

1.1

0.5 to 2.0

   30.0+

8 (4)

11 (3)

0.7

0.3 to 1.9

First-degree family history of breast cancerb

   Noa

140 (78)

240 (77)

1.0

-

   Yes

39 (22)

72 (23)

1.1

0.7 to 1.7

Parity

    

   Nulliparousa

72 (23)

27 (15)

1.0

-

   1 live birth

22 (7)

22 (12)

0.4

0.2 to 0.8

   2 live births

56 (17)

43 (24)

0.5

0.3 to 0.9

   3 live births

70 (22)

48 (25)

0.5

0.3 to 1.0

   4 live births

46 (14)

21 (12)

0.8

0.4 to 1.6

   5 or more live births

54 (17)

21 (12)

1.0

0.5 to 1.9

Geographical location

    

   Cape Cod, Massachusettsa

91 (50)

178 (56)

1.0

-

   Los Angeles, California

27 (15)

33 (10)

0.6

0.3 to 1.1

   Rhode Island

17 (9)

38 (12)

1.1

0.6 to 2.1

   Minnesota

28 (15)

34 (11)

0.6

0.3 to 1.1

   North Carolina

19 (10)

37 (12)

1.0

0.5 to 1.8

History of benign breast disease

   Noa

116 (65)

206 (65)

1.0

-

   Yes

63 (35)

110 (35)

1.0

0.7 to 1.4

  1. aReference level. bIncludes a woman's mother, sister(s), and/or daughter(s). -, not calculated; CI, confidence interval; NAT, N-acetyltransferase; OR, odds ratio.