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Table 2 Expression of laminin-8 and laminin-9 chains in breast tissue blood vessel basement membranes

From: Overexpression of β1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases

Sample

Diagnosis

Ln-α4

Ln-β1

Ln-β2

Ln-γ1

Ln typea

7

Normal

+

-

+++

+++

9

9

Normal

++

+

+++

+++

9

11

Normal

+

++

++++

+++

9

17

Normal

++

-

+++

++

9

21

Normal

-

-

+++

+++

9

25

Normal

+

-

+++

+++

9

32

Normal

++

+/-

+++

+++

9

75

Normal

+

+/-

+

++

9

77

Normal

+++

-

+++

+++

9

79

Normal

++

-

+

++

9

64

Normal

+

++

+

+++

8/9

65

Normal

+

+/-

-

++

9

66

Normal

++

+

-

+++

8

67

Normal

+

+

+

++

9

8

DCIS

++

++

+++

+++

8/9

22

DCIS

+++

+++

-

+++

8

32

DCIS

++

+/-

+++

+++

9

38

DCIS

++

+

++

++

9

41

DCIS

++

+

+++

+++

9

1

IDC

+++

++++

-

+++

8

2

IDC

+++

+++

-

+++

8

3

IDC

+++

+++

-

+++

8

5

IDC

++

++

-

++

8

6

IDC

++++

+++

-

+++

8

12

IDC

+

-

+

+++

9

14

IDC

++

+

++

+++

9

20

IDC

++++

++++

-

+++

8

22

IDC

+++

++

-

+++

8

24

IDC

++++

+++

++

+++

8/9

28

IDC

+++

+++

-

+++

8

30

IDC

+++

++

++

+++

8/9

34

IDC

+++

++

+++

+++

8/9

36

IDC

++++

++++

-

+++

8

76

IDC

+++

++

-

+++

8

78

IDC

++

++

-

+++

8

121

Metastasis

++++

+++

+/-

+++

8

146

Metastasis

++++

++++

-

+++

8

157

Metastasis

+++

+++

+/-

+++

8

  1. aPredominant laminin type is shown for each case; when some vessels had one isoform and the others had another, both are shown (see also Table 3). Staining intensity was graded as follows: -, no staining; +, weak staining; ++ distinct staining; +++, bright staining; ++++, very strong staining, /, some vessels in the same sample are in one category and some are in another category. Ln, laminin; DCIS, ductal carcinoma in situ; IDC, invasive ductal carcinoma.