- Paper Report
- Open Access
Chromosome 1 in breast cancer progression
- Mike Davies1
© Current Science Ltd 2000
- Published: 1 December 2000
- Chromosome 1
Whilst ductal carcinoma in situ (DCIS) is now recognised as a precursor of invasive ductal carcinoma (IDC), it is still unclear whether hyperplastic lesions such as ductal epithelial hyperplasia and atypical ductal hyperplasia (ADH) are precursors of DCIS. Some of the changes found in cancer and DCIS have also been seen in hyperplasias, including amplification of chromosome 1.
To investigate if chromosome 1 aneusomy could play an early causal role in hyperplasias of the breast and if chromosome 1 abnormalities parallel breast cancer progression.
Fluorescent in situ hybridisation was performed using a centromeric chromosome 1 probe (CEP1) on a series of seven carefully diagnosed hyperplasias that occurred concurrently with the carcinoma.
Mean signal number for the chromosome 1 probe was significantly greater in all breast lesions compared to adjacent normal tissue and no case of monosomy was seen. Values for chromosome 1 copy number in DCIS and IDC were similar and greater than those for hyperplasia and ADH, which were also similar to each other.
Whilst hyperplasias and ADH are considered markers for breast cancer risk, this study and other similar studies are starting to define the biological changes underlying these precancerous lesions. The role of chromosome 1 in benign proliferative disease of the breast is the subject of some debate in the literature, but in this study it would seem that the extent of chromosome 1 changes parallel histological progression.