Figure 5From: Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signallingIn vivo assessment of oestrogenic effect on breast cancer stem cells. (A) Growth curves for xenografts produced from 1,000 cells pre-treated ± 17β-estradiol, ± inhibitors. *P = 0.01 (B) In vivo tumour formation in each group represented as mice positive for growth/mice tested displayed for each cell number tested. Tumour initiating cell frequency (95% CI) estimates calculated from limiting dilution analysis.Back to article page